Tottenham's game away at Leicester this evening (Thursday) has been postponed due to Covid outbreaks.
It comes after reports of eight players and five staff members previously testing positive for the virus.
Spurs have now had their last three matches called off.
Leicester are also reportedly dealing with a Covid outbreak and their manager Brendan Rodgers previously expressing disappointment that the Premier League had initially rejected a request to postpone the fixture.
A league statement read: “The Premier League Board has postponed Leicester City FC’s match against Tottenham Hotspur tonight due to an increase in positive COVID-19 cases within Leicester’s squad today.
“In light of the new information, Leicester applied this morning for the fixture to be called off due to an ongoing outbreak within the squad, which has resulted in more players and staff testing positive for COVID-19 today.
“This has left the club with an insufficient number of players available to fulfil the game.
"Following consultation with the Premier League and UK Health Security Agency, the club’s first team training ground was closed this morning to help contain the outbreak.”
Tottenham had already travelled to Leicestershire on Wednesday and found out about the postponement at 12pm on Thursday, the PA news agency understands.
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